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ea0025oc5.4 | Reproduction and fetal programming | SFEBES2011

Impaired cardiac function in GR^−/− fetal mice

Rog-Zielinska Eva , Thomson Adrian , Moran Carmel , Brownstein David , Kenyon Christopher , Michailidou Zoi , Szumska Dorota , Bhattacharya Shoumo , Richardson Jennifer , Owen Elizabeth , Watt Alistair , Forrester Lesley , Holmes Megan , Chapman Karen

Glucocorticoid levels rise dramatically in late gestation in mammals and are essential for organ maturation in preparation for birth. They are widely used clinically to mature the lungs of premature infants and hypomorphic GR mice die neonatally due to severe lung atelectasis. Here, we describe fetal lethality in GR null (GR−/−) mice with 51% loss at E17.5 (P<0.05) that could be due to impaired cardiac development. Histology showed reduced hea...

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Endocrine Abstracts

Impaired cardiac function in GR^−/− fetal mice

BiosciAbstracts

Endocrine Abstracts

Impaired cardiac function in GR−/− fetal mice

BiosciAbstracts

Impaired cardiac function in GR^−/− fetal mice